KIM, Hark-Kyun,김학균,PARK, Jun-Won,박준원,JANG, Seok-Hoon,장석훈
申请号：
KRKR2014/002760
公开号：
WO2014/175567A1
申请日:
2014.04.01
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The present invention relates to an animal model of naturally occurring gastric cancer for evaluating efficacy and toxicity of immunotherapy and a therapeutic agent for gastric cancer, or identifying a metastasis-suppressor gene and developing a metastasis suppressor, and a gastric cancer cell line established therefrom. Specifically, it has been observed that the animal model of gastric cancer and the gastric cancer cell line established therefrom according to the present invention exhibited histopathologic characteristics similar to those of human gastric cancer and the size of the cancer cell was reduced by a 4-1BB inhibitor having an anti-cancer activity thus, the animal model of gastric cancer and the gastric cancer cell line established therefrom are useful for evaluating efficacy and toxicity of immunotherapy and a therapeutic agent for gastric cancer. One of the gastric cancer cell lines of the present invention metastasizes quickly and is thus useful for identifying genes associated with metastasis, developing a metastasis suppressor and evaluating efficacy thereof by comparing gene expression levels of the cell line and other cell lines. Accordingly, it has been proved that the animal model of gastric cancer and gastric cancer cell line of the present invention are useful for evaluating efficacy of a gastric cancer suppressor and a gastric cancer metastasis suppressor and evaluating immunotherapy, instead of immunosuppressed mice.La présente invention concerne un modèle animal de cancer de lestomac présent naturellement destiné à évaluer lefficacité et la toxicité dune immunothérapie et dun agent thérapeutique pour le cancer de lestomac, ou identifier un gène suppresseur de métastases et développer un suppresseur de métastases, et une lignée cellulaire de cancer de lestomac établie à partir de celui-ci. Spécifiquement, on a observé que le modèle animal de cancer de lestomac et la lignée cellulaire de cancer de lestomac établie à partir de celui-ci selon la
