Jean-Marie SAINT-REMY,Luc VANDER ELST,Vincent CARLIER
申请号：
US15151868
公开号：
US20160339121A1
申请日:
2016.05.11
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The application relates to methods for determining a parameter such as toxicity and pharmacokinetic behavior for a pharmaceutical compound against a disease or disorder. The test animals being used are non-human animals not suffering from or is not showing symptoms or signs of the disorder and which do not provoke an immune response against said pharmaceutical compound. These animals are obtainable by administration of a peptide comprising an oxidoreductase motif further comprising an NKT peptide epitope or an MCH class II T cell epitope of said pharmaceutical compound, wherein said motif and said epitope are separated by a linker of between 0 and 4 amino acids.
