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Angiotensin II receptor antagonists
专利权人:
Michael Man-Chu Lo;Amjad Ali
发明人:
Amjad Ali,Michael Man-Chu Lo
申请号:
US12864448
公开号:
US08106034B2
申请日:
2009.01.29
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A compound having the structurewherein R is an angiotensin receptor blocking groupY is —(CR1R20)1-7R5, or —C(O)(CR1R20)1-7R5;R1 and R20 are independently selected from the group consisting of hydrogen or C1-4 alkyl;R5 is —O—N═N(O)—NR3R4; andR3 and R4 are independently selected from the group consisting of —CH2CH2OH, —CH2CH2OCH3, —C1-4 alkyl, unsubstituted or substituted C1-6 alkenyl, unsubstituted or substituted morpholino, amino, unsubstituted or substituted benzyl, unsubstituted or substituted phenyl, unsubstituted or substituted arylC1-4 alkyl, or R3 and R4 together with the nitrogen atom to which they are attached, form a ring selected from the group consisting ofor a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of the stereoisomer thereof, which is useful for treating hypertension.
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