Almirante, Nicoletta,Nargund, Ravi P.,Ali, Amjad,Lo, Michael Man-Chu,Franklin, Chris,Sebhat, Iyassu K.,Stefanini, Silvia,Storoni, Laura
申请号:
AU2007334522
公开号:
AU2007334522B2
申请日:
2007.12.11
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
A compound having the structure (Formula I), wherein R is an angiotensin receptor antagonistactive group, Y is -Y-Y-Y-Y-Y.; Yis C(RR); R is selected from the group consistingof hydrogen and C alkyl; R is selected from the groupconsisting of hydrogen, C alkyl, and -0C(0)C alkyl;Y is O or CH; Y is C(O) or CH; Yis O or CH; Y5 is -(CH2) -(X)-(CH)- oris absent; X is -O- or - CRR-; and R and R areindependently selected from the group consisting of hydrogen and C-C alkyl;or a pharmaceutically acceptable salt or hydrate thereof, which is useful fortreating hypertension.