Brandt, Cameron,Howard, Edward D.,Chadwick, Eric M.,Gao, Zeren,West, James W.,Bilsborough, Janine,Levin, Steven D.,Ramsdell, Frederick J.
申请号：
AU2011265470
公开号：
AU2011265470A1
申请日:
2011.12.22
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2011265470A120120119.pdf#####Compositions and Methods for Modulating Immune Responses Abstract The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-I like molecule and is s expressed on T cells. The present invention also provides the discovery of zB7R1s ability to bind to CD155. Methods and compositions for modulating zB7RI-mediated negative signalling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided.
