The present invention relates to the compositions and purposes with what combination antiviral therapy, more particularly to contain [2- (6- Amino-purin -9- base) -1- methyl-ethoxymethyl]-phosphonic acids diisopropoxy carbonyloxymethyl ester (Viread,) and (2R Viread, 5S, it is cis-) -4- amino-5-fluorine -1- (2- methylol -1,3- oxathiolane -5- base)-(1H)-pyrimid-2-one (emtricitabine, Emtriva, (-)-cis- FTC) and its physiologic function derivative treatment combination. The combination can treat HIV infection with what, including the HIV mutant infection to nucleosides and/or non-nucleosidic inhibitors with drug resistance. The invention further relates to the pharmaceutical compositions and preparation of the combination containing the Viread and emtricitabine and its physiologic function derivative, and use the treatment method of this kind of composition and preparation.本發明涉及用於聯合抗病毒治療的組合物和用途，具體涉及含有[2-(6-氨基-嘌呤-9-基)-1-甲基-乙氧基甲基]-膦酸二異丙氧基羰基氧基甲基酯(替諾福韋地索普西富馬酸鹽，Viread®)和(2R,5S,順式)-4-氨基-5-氟-1-(2-羥甲基-1,3-氧硫雜環戊烷-5-基)-(1H)-嘧啶-2-酮(恩曲他濱，Emtriva™，(-)-順式FTC)及其生理學功能衍生物的治療聯合物。所述聯合物可用於治療HIV感染，包括被對核苷和/或非核苷抑制劑具有耐藥性的HIV突變株感染。本發明還涉及含有所述替諾福韋地索普西富馬酸鹽和恩曲他濱、及其生理學功能衍生物的聯合物的藥物組合物和製劑，以及使用這類組合物和製劑的治療方法。
