Method for lowering hypertension, raised total cholesterol, raised glucose and insulin, raised type-1 insulin like growth factor, raised triglycerides, and/or promote CRP and even up, promote that liver fat is not necessarily to have an adverse effect or lower these label/factors in the main body of the inferior grade with these labels are horizontal provides. Additionally provide a kind of method for promoting stem cell and regeneration and anti-inflammatory agents. Finally, additionally providing a kind of method for handling metabolic syndrome. The hypocaloric or the free food of card of simulation food or fasting are administered for period first time to main body, reduce the blood pressure or level of above-mentioned label/risk factor for aging and age-related disease.