LAI JIANN SHIUN,LAI YAN DA,WU YEN YU,TSAI YI JIUE,LIN YU YING
申请号：
IN8998/DELNP/2015
公开号：
IN2015DN08998A
申请日:
2015.09.30
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
An anti-VEGF antibody, or a binding fragment thereof, includes a heavy-chain variable region that comprises: (1) a CDRH1 sequence selected from SEQ ID NO: 17, 20, 23, 26, 29, 32, 35, or 38), (2) a CDRH2 sequence selected from SEQ ID o NO: 18, 21, 24, 27, 30, 33, 36, or 39, and (3) a CDRH3 sequence selected from SEQ ID NO: 19, 22, 25, 28, 31, 34, 37, or 40 and a light-chain variable region that comprises: (1) a CDRL1 sequence selected from SEQ ID NO: 41, 44, 47, 50, 53, 56, 59, or 62, (2) a CDRL2 sequence selected from SEQ ID NO: 42, 45, 48, 51, 54, 57, 60, or 63, and (3) a CDRL3 sequence selected from SEQ ID NO: 43, 46, 49, 52, 55, 58, 61, or 64. A method for treating or preventing a VEGF-related disorder, e.g., diabetic retinopathy, agerelated macular degeneration, or cancer, uses the antibodies.
