PROBLEM TO BE SOLVED: To provide a novel hENaCαβγ activator, a therapeutic agent for diseases and the like containing the same, and a salty taste enhancer. SOLUTION: 3-Chloro-N- (2-((1,1-dioxidetetrahydrothiophen-3-yl) amino) -2-oxoethyl) -N-ethylbenzo [β] thiophene represented by the following formula -2-Activator of hENaCαβγ containing a compound having the same or similar structure as carboxamide or a salt thereof as an active ingredient. [Selection diagram] FIG.【課題】新規のhENaCαβγ活性化剤、それを含有する疾患等の治療剤、塩味増強剤の提供。【解決手段】下記式で表される3-クロロ-Ｎ-(2-((1,1-ジオキシドテトラハイドロチオフェン-3-イル)アミノ)-2-オキソエチル)-Ｎ-エチルベンゾ[β]チオフェン-2-カルボキシアミドと同一若しくは類似構造を有する化合物又はその塩を有効成分とするhENaCαβγの活性化剤。【選択図】図２
