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COMPOSITIONS FOR LOCAL USE IN A GEL FORM CONTAINING SPECIAL SOLUBILIZED RETINOID
专利权人:
ГАЛДЕРМА РЕСЕРЧ ЭНД ДЕВЕЛОПМЕНТ (FR)
发明人:
ДЮПРА Аньес (FR),МАЛЛАР Клер (FR)
申请号:
RU2014152977
公开号:
RU2014152977A
申请日:
2013.05.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A pharmaceutical composition containing at least one compound of the general formula (I): wherein: R represents a hydrogen atom, an alkyl containing from 1 to 4 carbon atoms, or a —CF radical; —R represents a hydrogen atom, an alkyl or alkoxy group, containing from 1 to 4 carbon atoms, or a chlorine atom; - R represents a hydrogen atom, an alkyl or alkoxy group containing from 1 to 10 carbon atoms, which is linear or branched and optionally substituted by a methoxy group; - R represents a hydrogen atom or alkyl containing from 1 to 3 carbon atoms; - R represents a hydrogen atom or alkyl containing from 1 to 3 carbon atoms; - or R and R together with the —NC (= Y) fragment form a cycle such as pyrrolidine, pyrrolidinone, piperidine or piperidinone; - Y represents two hydrogen atoms or a heteroatom such as an oxygen atom, sulfur; - Ar represents a cycle of 1,4-phenyl, 2,5-pyridyl, 5,2-pyridyl or 2,5-thiophenyl; - X represents an oxygen atom, optional substituted by alkyl or alkylamine, or by a single C — C bond; - A represents a hydrogen atom or a group formula: where: - Q represents an oxygen atom or a linker —NH -; —R represents a hydrogen atom, alkyl containing from 1 to 6 carbon atoms, cycloalkyl containing from 3 to 6 carbon atoms, and the radical -C (O) CH or —C (O) CHCH; - R and R ′ independently represent a hydrogen atom or a hydroxyl group, provided that R and R ′ are not a hydroxyl group at the same time; - n is 0, 1, 2, 3, 4, or 5; water, at least one gelling agent, at least one hydrophilic solvent of the compound of formula (I) and at least about din hydrophilic auxiliary solvent of the compound of formula (I). 2. Compo1. Фармацевтическая композиция, содержащая по меньшей мере одно соединение общей формулы (I):где:- Rпредставляет собой атом водорода, алкил, содержащий от 1 до 4 атомов углерода, или радикал -CF;- Rпредставляет собой атом водорода, алкильную или алкоксигруппу, содержащую от 1 до 4 атомов углерода, или атом хлора;- Rпредставляет собой атом
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中国工程科技知识中心
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