The present invention relates to a complex that includes mequitazine, a cyclodextrin, and an interaction agent wherein the rate of solubilization in water of complexed mequitazine, measured for a 2 g/l mixture of mequitazine in water at 35° C. after 15 minutes of stirring, is greater than 50% at pH 9. The present invention also relates to a method of preparing the aforementioned complex and a pharmaceutical composition of which the complex is a part.本發明係關於一種含有甲喹吩、環糊精及反應劑的複合物,其中複合化甲喹吩於水中的溶解速率在35℃水中以2克/升甲喹吩混合物攪拌15分鐘後在pH 9下測定時係大於50%。本發明亦係關於製備上述之複合物及以複合物為其一部分之醫藥組成物的方法。