シクロデキストリン・ドセタキセルの包接体を含む薬物組成物及びその製造方法

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专利权人:

ハイナン ハデトン サイエンス アンド テクノロジー コー.エルティーディー

发明人:

イン,ヨン,ガオ,ジャンフォン,ユ,シュチン,ウ,リン

申请号：

JP2009526995

公开号：

JP5103476B2

申请日:

2006.10.13

申请国别(地区):

JP

年份:

2012

代理人:

摘要：

A docetaxel inclusion complex having improved water-solubility (up to 15mg/ml) and stability (stability constant Ka=2056M -1 -13051M -1 ), comprises docetaxel and hydroxypropyl-beta-cyclodextrin and/or sulfobutyl-beta-cyclodextrin in a ratio of 1:10-150. The method includes steps as follows: docetaxel dissolved in ethanol is added into water solution of cyclodextrin via stirring, until docetaxel is completely dissolved said solution is filtered in 0.2-04 &mgrm microporous membrane then ethanol is removed through reduced pressure to obtain the inclusion complex in a liquid form or ethanol, followed by water is removed through reduced pressure, then dried to obtain the inclusion complex in a solid form.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/