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PHARMACEUTICAL COMPOSITION CONTAINING DOCETAXEL-CYCLODEXTRIN INCLUSION COMPLEX AND ITS PREPARING PROCESS
专利权人:
发明人:
Yong Ren,Jianfeng Gao,Shuqin Yu
申请号:
US13932434
公开号:
US20130296268A1
申请日:
2013.07.01
申请国别(地区):
US
年份:
2013
代理人:
摘要:
A docetaxel inclusion complex having improved water-solubility (up to 15 mg/ml) and stability (stability constant Ka=2056 M−1-13051 M−1), comprises docetaxel and hydroxypropyl-beta-cyclodextrin and/or sulfobutyl-beta-cyclodextrin in a ratio of 1:10-150. The method includes steps as follows: docetaxel dissolved in ethanol is added into water solution of cyclodextrin via stirring, until docetaxel is completely dissolved said solution is filtered in 0.2-04 μm microporous membrane then ethanol is removed through reduced pressure to obtain the inclusion complex in a liquid form or ethanol, followed by water is removed through reduced pressure, then dried to obtain the inclusion complex in a solid form.
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