Cinnamoyl-piperazine derivatives and their use as PAR-1 antagonists

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专利权人:

ピエール、ファーブル、メディカマン

发明人:

ミシェル、ペレ,マリー、ラモト,ブルーノ、ル、グラン,ロベール、ルティエンヌ

申请号：

JP2009515860

公开号：

JP5356222B2

申请日:

2007.06.19

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

The present invention relates to compounds of general formula (I): wherein: R1 represents: halogen, CN or NO2； R2 represents: hydrogen or halogen； n represents: 1 or 2； R3 represents: phenyl substituted by one or more halogens or C1-C6 alkyls； or a cyclohexyl； as well as the therapeutically-acceptable salts or solvates thereof. These compounds are useful as protease-activated receptor-1 (PAR-1) antagonists, particularly in the treatment of thrombosis.

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