您的位置：
首页
>
农业专利
>
详情页
delayed release drug formulation and method for producing a delayed release drug formulation
- 专利权人:
- TILLOTTS PHARMA AG
- 发明人:
- Abdul Waseh Basit,Ana Cristina Freire,Felipe José Oliveria Varum,Frédéric Jean-Claude Goutte,Roberto Carlos Bravo González,Thomas Buser
- 申请号：
- BR112014026935
- 公开号：
- BR112014026935A2
- 申请日:
- 2013.04.29
- 申请国别(地区):
- BR
- 年份:
- 2017
- 代理人:
- 摘要：
- 1/1 summary “delayed release drug formulation, and method to produce a delayed release drug formulation” delayed release of a drug to the colon It is obtained from a delayed release formulation comprising a core and a core coating. the core comprises a drug and the coating comprises an outer layer and at least one layer between the core and the outer layer selected from the group consisting of an insulation layer and an inner layer. the outer layer comprises a mixture of a first polymeric material that is susceptible to attack by colonic bacteria, and a second polymeric material that has a ph threshold around or above ph 5. the inner layer comprises a third polymeric material that is soluble in intestinal fluid or gastrointestinal fluid, said third polymeric material being selected from an at least partially neutralized polycarboxylic acid and a nonionic polymer. In embodiments wherein the third polymeric material is a nonionic polymer, the inner layer comprises at least one of a buffering agent and a base. The insulation layer comprises a nonionic polymer that is soluble in intestinal fluid or gastrointestinal fluid. The outer coat is applied directly to the inner layer or insulation layer using a coating preparation formed by combining the first polymeric material in an aqueous medium with a second polymeric material. rich in an organic medium. Advantages of formulations according to the present invention include accelerated release of the drug when exposed to colonic conditions and reduction or elimination of an effect. of food and / or alcohol on drug release after administration.1 / 1 resumo “formulaã‡ãƒo de droga de liberaã‡ãƒo retardada, e, mã‰todo para produzir uma formulaã‡ãƒo de droga de liberaã‡ãƒo retardadaâ€� a liberaã§ã£o retardada de uma droga ao cã³lon ã© obtida a partir de uma formulaã§ã£o de liberaã§ã£o retardada que compreende um nãºcleo e um revestimento para o nãºcleo. o nãºcleo compreende uma droga e o revestimento compreende uma camada exter
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
