Delayed release of a drug to the colon is achieved by delayed release coating, which includes a core and a core coating. The core consists of a drug and a coating, an inner layer and at least one C.Between the core and the selected outer layer, it consists of an insulating layer and an inner layer. The shell is a mixture of the first polymer that could be attacked by Columbus bacteria.The second kind of polymetallic substance has a pH threshold of about 5 or higher. The inner layer consists of a third polygonal substance that can be dissolved in intestinal or gastrointestinal juices. The third polygonal substance is selected from at least partially neutralized polygonal acids and nonionic polymers. In the third mode of polymerizing nonionic materials,The inner layer includes at least one buffer and a base. The Islamic layer consists of a nonionic polymer that can be dissolved in intestinal or gastrointestinal juices. Appearance is a half-water and the second polymer is an organic environment. B. Benefits of the present formE inventions include: accelerating the release of a drug when it is in a state of illness； reducing or eliminating the effects of food and/or alcohol on drug release； and managing. Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a COACheers to the core! The core includes a drug and the coating includes an outer layer and at least one layer between the core and the outer layer selected from the group consisting of an isolation layer and an inner layer. The outer layer comprises a mixture of a first polymeric material which is susable to attack by colonic bacteriaAnd a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer contains a third polymeric material which is solble in intestinal or gastrointestinal fluids, said third polymeric material is selected from an least partially neutralized polycarboxylic acid and a non-ionic polymer. In embodiments in w
