THE UNITED STATES OF AMERICA, as represented by The Secretary, Department of Health and Human Services;THE UNITED STATES OF AMERICA; as represented by The Secretary;KITE PHARMA, INC.; Department of Health and Human Services
发明人:
BOT, Adrian,WIEZOREK, Jeffrey S.,GO, William,JAIN, Rajul,KOCHENDERFER, James N.,ROSENBERG, Steven A.
申请号:
PH12017502153
公开号:
PH12017502153A1
申请日:
2017.11.27
申请国别(地区):
PH
年份:
2018
代理人:
摘要:
The invention provides methods of increasing the efficacy of a T cell therapy in a patient in need thereof. The invention includes methods of identifying a patient who would respond well to a T cell therapy or conditioning a patient prior to a T cell therapy so that the patient responds well to a T cell therapy. The conditioning involves administering one or more preconditioning agents prior to a T cell therapy and identifying biomarker cytokines prior to administering a T cell therapy.