Methods of improving RNAi in well-differentiated airway epithelia

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专利权人:

University of Iowa Research Foundation

发明人:

McCray, Jr. Paul B.,Davidson Beverly L.,Apicella Michael A.,Krishnamurthy Sateesh

申请号：

US201514703536

公开号：

US9987299(B2)

申请日:

2015.05.04

申请国别(地区):

美国

年份:

2018

代理人:

Viksnins Harris Padys Malen LLP

摘要：

The present invention relates to methods of reducing a level of a target mRNA in a well-differentiated airway epithelial cell by contacting the cell with a facilitating agent followed by contacting the cell with a therapeutic RNAi agent, wherein the facilitating agent comprises a Platelet-activating factor receptor (PAFR) ligand.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/