FISCHER LAURENT JEAN-CHARLES,BARZU-LE ROUX SIMONA,AUDONNET JEAN-CHRISTOPHE FRANCIS
申请号：
PL35221200
公开号：
PL210451B1
申请日:
2000.06.08
申请国别(地区):
PL
年份:
2012
代理人:
摘要：
The invention aims at improving the efficacy and protection induced by DNA vaccination against viruses of the family of Paramyxoviridae and against the herpes virus, in pets and sport animals. The improvement of DNA vaccination is achieved either by formulating the vaccine with a cationic lipid containing a quaternary ammonium salt, DMRIE, or by modifications in the nucleotide sequence coding for the antigen of interest in particular of deletions of the fragment of the nucleotide sequence coding for the transmembrane domain of the antigen of interest, and/or insertions of introns and/or insertions of nucleotide sequences coding for the signal peptides, or by adding GM-CSF, or by combinations thereof. The invention also concerns the resulting vaccines.
