Disclosed is a vector comprising a first polynucleotide encoding a Canine Distemper Virus hemagglutinin (CDV HA) polypeptide and a second polynucleotide encoding a Granulocyte-macrophage colony-stimulating factor (GM-CSF) polypeptide. Further disclosed is a composition comprising: a) an expression vector, wherein the vector comprises a first polynucleotide encoding a Canine Distemper Virus hemagglutinin (CDV HA) polypeptide and a second polynucleotide encoding a Granulocyte-macrophage colony-stimulating factor (GMCSF) polypeptide and b) a pharmaceutically or veterinary acceptable vehicle, adjuvant, diluent or excipient.