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КОМПОЗИЦИИ РЕКОМБИНАНТНОГО CDV И ЕЕ ПРИМЕНЕНИЕ
专利权人:
МЕРИАЛ ЛИМИТЕД (US)
发明人:
ОДОННЕ Жан-Кристоф (FR),МИНКЕ Жюль (FR)
申请号:
RU2012140741/10
公开号:
RU2012140741A
申请日:
2011.02.25
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A composition soderzhaschayaa) expression vector, wherein the vector comprises a polynucleotide encoding one or more polypeptides selected from the group consisting of a polypeptide CDV HA polypeptide GM-CSF, and mixtures thereof and b) a pharmaceutically or veterinarily acceptable carrier, adjuvant, diluent or ekstsipient.2. A composition according to claim 1, wherein the vector comprises a first polynucleotide encoding a polypeptide CDV HA and a second polynucleotide encoding a polypeptide GM-CSF.3. The composition of claim 2, further comprising one or more additional antigenov.4. A composition according to claim 3, wherein the additional antigen is a canine antigen selected from the group consisting of the rabies virus, canine parvovirus, canine coronavirus, canine influenza virus, infectious canine hepatitis, canine herpes, psevdobeshestva, canine parvovirus type I, Leptospira and Neospora caninum.5. A composition according to claim 2, wherein the first polynucleotide encodes a polypeptide CDV HA, having at least 80% sequence identity with the sequence shown in SEQ ID NO: 2, wherein the second polynucleotide encodes GM-CSF polypeptide having at least 80% sequence identity with the sequence shown in SEQ ID NO: 4.6. A composition according to claim 1, wherein the polynucleotide encodes a polypeptide CDV HA, having at least 80% sequence identity with the sequence shown in SEQ ID NO: 2.7. A composition according to claim 1, wherein the polynucleotide encodes GM-CSF polypeptide having at least 80% sequence identity with the sequence shown in SEQ ID NO: 4.8. A composition according to claim 1, wherein the polynucleotide has at least1. Композиция, содержащаяa) экспрессирующий вектор, при этом вектор содержит полинуклеотид, кодирующий один или несколько полипептидов, выбранных из группы, состоящей из полипептида CDV НА, полипептида GM-CSF и их смесей иb) фармацевтически или ветеринарно приемлемый носитель, адъювант, разбавитель или эксципиент.2. Композиция по п.1, пр
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