The present invention belongs to pharmaceutical technology field,More particularly to shown in logical formula (I) as mineralocorticoid receptor antagonists and cyclics,Its pharmaceutically acceptable salt and its isomers,The preparation method of these compounds,Pharmaceutical preparation containing these compounds,And these compounds,Its pharmaceutically acceptable salt or its isomers preparation treatment and/or prevention injury of kidney,Cardiovascular disease such as hypertension,And/or the application in the drug of endocrine system disease,Wherein X,Y1,Y2,Y3,R1,R2a,R2b,R3a,R3b,R4,Cy and n are defined as in the description.本發明屬於醫藥技術領域，具體涉及通式(I)所示的作爲鹽皮質激素受體拮抗劑的并環類化合物、其藥學上可接受的鹽及其異構體，這些化合物的製備方法，含有這些化合物的藥物製劑，以及這些化合物、其藥學上可接受的鹽或其異構體在製備治療和/或預防腎損傷、心血管疾病如高血壓、和/或內分泌疾病的藥物中的應用，其中X、Y1、Y2、Y3、R1、R2a、R2b、R3a、R3b、R4、Cy和n如說明書中所定義。
