The invention provides novel compounds having the general formula I:wherein R1, X, Z1to Z5, L, n, the A ring, and the B ring, are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.本發明提供具有通式I之新穎化合物:其中R1、X、Z1至Z5、L、n、A環及B環如本文中所描述, 包括該化合物的醫藥組合物和使用該化合物之方法。