The invention provides novel compounds having the general formula I:wherein R1, X, Z1, L, n, the A ring, the B ring, and the C ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.本發明提供具有通式I之新穎化合物,其中R1、X、Z1、L、n、A環、B環及C環如本文所述;包括該等化合物之醫藥組合物;及使用該等化合物之方法。