Thomas Friedl;Nantharat Pearnchob;Karl Gerhard Wagner;Florian Sommer
发明人:
Nantharat Pearnchob,Thomas Friedl,Karl Gerhard Wagner,Florian Sommer
申请号：
US11837962
公开号：
US08512748B2
申请日:
2007.08.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention is directed to a pharmaceutical controlled release system for administration, particularly oral administration, of active substances with pH-dependent solubilities, comprisinga) a core material containing or consisting of one or more pharmaceutically acceptable pH modifiers；b) optionally an insulating layer,c) a first layer containing or consisting of one or more pharmaceutically acceptable water-insoluble polymers；d) a second layer containing or consisting of at least one active substance having a pH-dependent solubility；e) a third layer containing or consisting of one or more pharmaceutically acceptable polymers having anionic or no ionic groups； andf) optionally a fourth layer, preferably in form of an outer coating layer.It is provided a pH-independent release profile of active substances having pH-dependent solubilities in vitro and vivo.
