NANTHARAT PEARNCHOB,THOMAS FRIEDL,KARL GERHARD WAGNER,FLORIAN SOMMER,PEARNCHOB NANTHARAT,FRIEDL THOMAS,WAGNER KARL GERHARD,SOMMER F
申请号：
BRPI0716436
公开号：
BRPI0716436A2
申请日:
2007.08.10
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
The invention is directed to a pharmaceutical controlled release system for administration, particularly oral administration, of active substances with pH-dependent solubilities, comprising a) a core material containing or consisting of one or more pharmaceutically acceptable pH modifiers； b) optionally an insulating layer, c) a first layer containing or consisting of one or more pharmaceutically acceptable water-insoluble polymers； d) a second layer containing or consisting of at least one active substance having a pH-dependent solubility； e) a third layer containing or consisting of one or more pharmaceutically acceptable polymers having anionic or no ionic groups； and f) optionally a fourth layer, preferably in form of an outer coating layer. It is provided a pH-independent release profile of active substances having pH-dependent solubilities in vitro and vivo.
