PEARNCHOB, NANTHARAT,FRIEDL, THOMAS,WAGNER, KARL GERHARD,SOMMER, FLORIAN
申请号：
CA2661613
公开号：
CA2661613C
申请日:
2007.08.10
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention is directed to a pharmaceutical controlled release system for administration, particularly oral administration, of active substances with pH- dependent solubilities, comprising a) a core material containing or consisting of one or more pharmaceutically acceptable pH modifiers； b) optionally an insulating layer, c) a first layer containing or consisting of one or more pharmaceutically acceptable water-insoluble polymers； d) a second layer containing or consisting of at least one active substance having a pH-dependent solubility； e) a third layer containing or consisting of one or more pharmaceutically acceptable polymers having anionic or no ionic groups； and f) optionally a fourth layer, preferably in form of an outer coating layer. It is provided a pH-independent release profile of active substances having pH- dependent solubilities in vitro and vivo.
