Per ANTONI,Malin ERIKSSON,Anna GÄLLHAGEN,Eva KOCH,Daniel NYSTRÖM,Christian PORSCH-GRAHM,Helena GÖRANSSON
申请号：
US16297064
公开号：
US20190275212A1
申请日:
2019.03.08
申请国别(地区):
US
年份:
2019
代理人:
摘要：
According to the invention there is provided inter alia a process for the manufacture of a solid object having a surface comprising a layered coating of cationic and anionic polymer wherein the outer coating layer comprises an anticoagulant entity, comprising the steps of:i) treating a surface of the solid object with a cationic polymer；ii) treating the surface with an anionic polymer；iii) optionally repeating steps i) and ii) one or more times；iv) treating the surface with a cationic polymer； andv) treating the outermost layer of cationic polymer with an anticoagulant entity, thereby to covalently attach the anticoagulant entity to the outermost layer of cationic polymer； wherein, the anionic polymer is characterized by having (a) a total molecular weight of 650 kDa-10,000 kDa； and (b) a solution charge density of >；4 μeq/g； and wherein, step ii) is carried out at a salt concentration of 0.25 M-5.0 M.
