PROBLEM TO BE SOLVED: To provide an agent for inhibiting ubiquitination of a protein and an agent for the treatment of fibrosis.SOLUTION: The invention provides a ubiquitination inhibiting agent for proteins containing at least one substance selected from plumbagin and quercetin, their salts or their hydrates, and provides a fibrosis treating agent containing plumbagin, its pharmacologically permissible salt or their hydrate.COPYRIGHT: (C)2008,JPO&INPIT【課題】タンパク質のユビキチン化抑制剤及び線維症治療剤の提供。【解決手段】プルムバギン及びケルセチンからなる群から選ばれる少なくとも1つ、これらの塩又はこれらの水和物を含む、タンパク質のユビキチン化抑制剤、並びに、プルムバギン、その製薬上許容可能な塩又はこれらの水和物を含む、線維症治療剤を提供する。【選択図】なし
