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COMPOSE L-PROLINE D'UN INHIBITEUR DU COTRANSPORTEUR SODIUM-GLUCOSE DE TYPE 2, AINSI QUE MONOHYDRATE ET CRISTAL DU COMPOSE L-PROLINE
专利权人:
JIANGSU HENGRUI MEDICINE CO.; LTD.
发明人:
SUN, PIAOYANG,WU, GUAILI,GUO, CHANGSHAN,LU, YUN,WU, YUXIA,SHEN, LINGJIA
申请号:
CA2961819
公开号:
CA2961819A1
申请日:
2015.09.08
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
Provided are an L-proline compound of a sodium-glucose cotransporter 2 inhibitor, and a monohydrate and a crystal of the L-proline compound. Specifically, provided are 1,6-dehydrated-1-C{4-chloro-3-[(3-fluoro-4-ethoxyphenyl)methyl]phenyl}-5-C-(hydroxymethyl)-ß-L-idopyranose L-proline (a compound of formula (I)), a monohydrate and an A-type crystal thereof and a preparation method therefor. The obtained A-type crystal of the compound of formula (I) has good chemical stability and crystal stability, and a crystallization solvent used has low toxicity and low residue, so the A-type crystal can be better used in clinical treatment.
来源网站:
中国工程科技知识中心
来源网址:
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