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L-PROLINE COMPOUND OF SODIUM-GLUCOSE COTRANSPORTER 2 INHIBITOR, AND MONOHYDRATE AND CRYSTAL OF L-PROLINE COMPOUND
专利权人:
Jiangsu Hengrui Medicine Co. Ltd.
发明人:
SUN, Piaoyang,WU, Guaili,GUO, Changshan,LU, Yun,WU, Yuxia,SHEN, Lingjia
申请号:
EP15846001
公开号:
EP3202772A4
申请日:
2015.09.08
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
Provided are an L-proline compound of a sodium-glucose cotransporter 2 inhibitor, and a monohydrate and a crystal of the L-proline compound. Specifically, provided are 1,6-dehydrated-1-C{4-chloro-3-[(3-fluoro-4-ethoxyphenyl)methyl]phenyl}-5-C-(hydrox ymethyl)-²-L-idopyranose L-proline (a compound of formula (I)), a monohydrate and an A-type crystal thereof and a preparation method therefor. The obtained A-type crystal of the compound of formula (I) has good chemical stability and crystal stability, and a crystallization solvent used has low toxicity and low residue, so the A-type crystal can be better used in clinical treatment.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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