BRAIN, Christopher Thomas,THOMA, Gebhard,SUNG, Moo Je
申请号：
ES07811927
公开号：
ES2623133T3
申请日:
2007.05.24
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt or solvate thereof, in which: the broken line indicates a double bond； A is N or CR5, wherein R5 is hydrogen or C1-C3 alkyl； R2 and R3 are each independently selected from the group consisting of hydrogen, hydroxyl, C1-C3 alkyl, C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, substituted C1-C3 alkyl, substituted C3-C8 cycloalkyl, substituted heterocyclyl, substituted aryl and substituted heteroaryl； R4 is selected from the group consisting of C (H) (CH2CH3) 2, C (H) (CH2CH3) Ph, CH2CH3, cyclopropyl, cyclopentyl or cyclohexyl； X is N or CR11 and Y is CR12； R11 is selected from the group consisting of halo, hydrogen, C1-C3 alkyl, C1-C3 alkoxy, CN, C>； = NOH, C>； = NOCH3, C (O) H, C (O) C1-C3 alkyl, cycloalkyl C3-C8, heterocyclyl, aryl, heteroaryl, substituted C1-C3 alkyl, substituted C3-C8 cycloalkyl, substituted heterocyclyl, substituted aryl, substituted heteroaryl, -BNR13R14, -BOR13, -BC (O) R13, - BC (O) OR13 , -BC (O) NR13R14； wherein B is a bond, C1-C3 alkyl or branched C1-C3 alkyl； wherein R13 and R14 are each independently selected from the group consisting of hydrogen, C1-C3 alkyl, C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, substituted alkyl, substituted cycloalkyl, substituted heterocyclyl, substituted aryl, and heteroaryl substituted and R12 is -BC (O) NR13R14； wherein B is a bond, C1-C3 alkyl or branched C1-C3 alkyl； wherein R13 and R14 are each independently selected from the group consisting of hydrogen, C1-C3 alkyl, C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, substituted alkyl, substituted cycloalkyl, substituted heterocyclyl, substituted aryl, and heteroaryl replaced.Un compuesto de la Fórmula I:**Fórmula** o una sal o solvato farmacéuticamente aceptables del mismo, en la que: la línea discontinua indica un enlace doble； A es N o CR5, en la que R5 es hidrógeno o alquilo C1-C3； R2 y R3 están cada uno, independientemente, seleccionados del grupo que consiste e
