Picci Marie,Sigg Juergen,Royer Christophe,Bryant Andrew Mark,Buettgen Heinrich Martin
申请号：
NZ70298013
公开号：
NZ702980A
申请日:
2013.01.25
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
The present invention provides a pre-filled syringe, the syringe comprising a glass body, a stopper and a plunger, the body comprising an outlet at an outlet end and the stopper being arranged within the body such that a front surface of the stopper and the body define a variable volume chamber from which a fluid can be expelled though the outlet, the plunger comprising a plunger contact surface at a first end and a rod extending between the plunger contact surface and a rear portion, the plunger contact surface arranged to contact the stopper, such that the plunger can be used to force the stopper towards the outlet end of the body, reducing the volume of the variable volume chamber, characterised in that the fluid is an ophthalmic solution which comprises a VEGF-antagonist wherein: (a) the syringe has a nominal maximum fill volume of between about 0.5ml and about 1ml, (b) the syringe is filled with a dosage volume of between about 0.03ml and about 0.05ml of said VEGF antagonist solution, (c) the syringe barrel comprises less than about 100µg silicone oil, (d) the VEGF antagonist solution comprises no more than 2 particles >；50µm in diameter per ml, and (e) the syringe has a stopper break loose force of less than about 11 N. The syringe is particularly a small volume syringe such as a syringe suitable for ophthalmic injections.
