Disclosed are a compound as shown by general formula (I) or a stereoisomer, a hydrate, a metabolite, a solvate, a pharmaceutical acceptable salt and an eutectic or a prodrug thereof, and a preparation method and a use in the preparation of drugs for treating airway obstructive diseases, wherein in the general formula (I), the definition of each substituent is the same as that in the description.一種通式(I)所示的化合物或其立體異構物、水合物、代謝產物、溶劑化物、藥學上可接受的鹽、共晶或前藥,以及製備方法和在製備用於治療氣道阻塞性疾病藥物中的應用,其中通式(I)化合物為其中,各取代基的定義與說明書中一致。