Andrea POLZER;Ingo KLAGGE;Gabriela WOCHNIK-VELTRUP;Christoph HEUSSER;Christoph SCHWAERZLER;José M. CARBALLIDO HERRERA;Stefan HARTLE
发明人:
José M. CARBALLIDO HERRERA,Stefan HARTLE,Christoph HEUSSER,Ingo KLAGGE,Andrea POLZER,Christoph SCHWAERZLER,Gabriela WOCHNIK-VELTRUP
申请号：
US13252721
公开号：
US20120082681A1
申请日:
2011.10.04
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to antibodies that specifically bind to IL12Rβ1, the non-signal transducing chain of both the heterodimeric IL12 and IL23 receptors. The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/1L18 induced IFNγ production of blood cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFNγ production, IL12 and/IL23 signaling, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.
