Jose M. Carballido Herrera;Christoph Heusser;Christoph Schwaerzler;Michael Bardroff;Ute Jaeger;Daniela Della Ducata
发明人:
Michael Bardroff,Jose M. Carballido Herrera,Daniela Della Ducata,Christoph Heusser,Ute Jaeger,Christoph Schwaerzler
申请号：
US13265346
公开号：
US08715657B2
申请日:
2010.03.29
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to antibodies that specifically bind to IL12Rβ1, the non-signal transducing chain of the heterodimeric IL12 receptor (together with IL12Rβ2 chain) as well as IL23 receptor (together with IL23Rα chain). The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/IL18 induced IFNγ production of T cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFNγ production, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.
