Andrea Polzer;Ingo Klagge;Jose M. Carballido Herrera;Gabriela Wochnik-Veltrup;Christoph Heusser;Christoph Schwaerzler;Stefan Hartle
发明人:
Jose M. Carballido Herrera,Stefan Hartle,Christoph Heusser,Ingo Klagge,Andrea Polzer,Christoph Schwaerzler,Gabriela Wochnik-Veltrup
申请号：
US14045276
公开号：
US08945548B2
申请日:
2013.10.03
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to antibodies that specifically bind to IL12Rβ1, the non-signal transducing chain of both the heterodimeric IL12 and IL23 receptors. The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/IL18 induced IFNγ production of blood cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFNγ production, IL12 and/IL23 signaling, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.
