SMALL MOLECULE INHIBITORS OF NECROPTOSIS

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专利权人:

President and Fellows of Harvard College

发明人:

Yuan, Junying,Hsu, Emily S.

申请号：

AU2016202262

公开号：

AU2016202262A1

申请日:

2016.04.12

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

#$%^&*AU2016202262A120160512.pdf#####ABSTRACT The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-a) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I)-(VIll) and by Compounds (l)-(l), (13)-(26), (27)-(33), (48)-(57), and (58)-(70). These necrostatins are shown to inhibit TNF-a induced necroptosis in FADDdeficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring necrostatins. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/