Muhammed Yildirim,Holger Gruell,Rudolf Mathias Johannes Nicolaas Lamerichs
申请号：
US13387748
公开号：
US20120128589A1
申请日:
2010.07.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Described is the use of perfluoro-t-butyl cyclohexane in a contrast agent for molecular imaging, notably F MRI. Particularly, the perfluoro-t-butyl cyclohexane is present in the form of an aqueous emulsion of nanoparticles comprising the perfluoro compound as a core, and an emulsifying agent, such as a phospholipid, as a shell. The shell can be functionalized with other moieties that play a role in imaging, notably ligands for targeted binding and/or contrast agents or labels with a view to other imaging modalities. The latter particularly refers to 1H MRI contrast agents as well as radiolabels for SPECT.
