President and Fellows of Harvard College;Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences;Tufts University;University of Houston
发明人:
Junying Yuan,Alexei Degterev,Gregory D. Cuny
申请号：
US14214360
公开号：
US09725452B2
申请日:
2014.03.14
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to heterocyclic compounds (e.g., compounds described by Formula (I)) and pharmaceutically acceptable salts thereof. The invention also features pharmaceutical compositions that include these compounds and their use in therapy for treating conditions in which necroptosis is likely to play a substantial role. The heterocyclic compounds described herein can also achieve improved activity and selectivity towards RIP1 and/or RIP3.
