Processes for the preparation of cis-4-[2-{[(3S,4R)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9H-purin-9-yl]-1-methylcyclohexane-1-carboxamide

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专利权人:

Celgene Corporation

发明人:

Zheng Chen,Maryll Elaine Geherty,Matthew Michael Kreilein,Xiaoling Lu,Nanfei Zou

申请号：

US16150345

公开号：

US10590136B2

申请日:

2018.10.03

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Provided herein are processes for the preparation of cis-4-[2-{[(3S,4R)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9H-purin-9-yl]-1-methylcyclohexane-1-carboxamide, alternatively named (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide, or a salt, solvate, hydrate, or isotopologue thereof.

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