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Method for stabilizing plasma protein cryoprecipitates for use in virus-inactivated heat treatment
专利权人:
ラボラトワール、フランセ、デュ、フラクショヌマン、エ、デ、ビオテクノロジ
发明人:
バルダ アニー,ビギン エディス
申请号:
JP2006518297
公开号:
JP4925822B2
申请日:
2004.07.08
申请国别(地区):
JP
年份:
2012
代理人:
摘要:
The invention relates to a method for obtaining cryoprecipitatable proteins, comprising a viral inactivation step by thermally treating a lyophilisate of these proteins, comprising, before rendering the proteins in the form of a lyophilisate, an initial addition step, to these proteins, of a stabilizing and solubilizing formulation containing a mixture consisting of arginine, at least one hydrophobic amino acid and of tribasic sodium citrate. The invention also relates to a concentrate consisting of at least one cryoprecipitable protein containing the stabilizing and solubilizing formulation introduced according to the method and being suited for therapeutic use.
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