Disclosed are 1-(aryl and heteroaryl)-1H-pyrrolo[2,3-c]pyridine derivatives as represented by the general formula (I), wherein R1 is optionally substituted phenyl or optionally substituted 6-membered heteroaryl R2 is -B-Q-[R3]n or -B-R3 wherein n = 1, 2, 3, or 4 B is a bond, O, or C1-3-alkylene Q is selected from: (i) a saturated or partially unsaturated monocyclic 3-7 membered heterocyclic ring or a C3-7-cycloalkyl ring, or (ii) a bridged heterocyclic or cycloalkyl ring selected from homomorpholine, tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl, morpholinyl, cyclohexyl wherein the bridge is formed by an ethylene or propylene radical Y is selected from hydrogen, hydroxyl, amino, -NHR6 or -OCH3 Z is selected from hydrogen, fluorine, hydroxyl, alkoxy, amino, -NHR6 W is selected from H, alkyl or haloalkyl and wherein the remaining substituents are as defined herein. Representative compounds include 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2,3,6-tetrahydropyridine, tert-butyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate, 1-(4-chlorophenyl)-3-piperidin-4-yl-1H-pyrrolo[5 2,3-c]pyridine, tert-butyl N-{ 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]cyclohexyl} carbamate, 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]cyclohexan-1-amine, 4-[1-(4-chloro-2-methylphenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]cyclohexan-1-amine, 1-{ 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl} -2-(dimethylamino)ethan-1-one, 1-{ 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridine-3-yl]piperidin-1-yl} -2-hydroxyethan-1-one, 2-amino-1-{ 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl} ethan-1-one, 3-amino-1-{ 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl} propan-1-one, 2-{ 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl} ethan-1-ol, 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-1-(1H-pyrazol-3-ylmethyl)piperidine, 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3
