O'CONNOR-MCCOURT, MAUREEN D.,SULEA, TRAIAN,ZWAAGSTRA, JOHN C.,COLLINS, CATHERINE,BAARDSNES, JASON
申请号：
CA2737271
公开号：
CA2737271C
申请日:
2009.09.17
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
The invention provides hereto-multivalent ligand binging agents (traps) formembers of the TGF-.beta. superfamily, as well as methods for making and usingsuch constructs. In an embodiment of the invention there is provided ahereto-multivalent binding agent with affinity for a member for the TGF-.beta.superfamily,said agent comprising the general structure (l): (<；bd1 >；-linker)k-[ {<；bdl>；-linker2-<；bd2>；-linker 3f-}n -(<；bd3>；)m-(linker4-<；bd4>；)d]h, where bd1, bd2, bd3 and bd4arepolypeptide binding domains having an affinity for different sites on the samemember or for different members of the TGF-.beta. superfamily, wherein atleast twoof bd1, bd2, bd3 , and bd4 are different from each other.
