O'CONNOR-MCCOURT, MAUREEN D.,SULEA, TRAIAN,ZWAAGSTRA, JOHN C.,BAARDSNES, JASON,COLLINS, CATHERINE,OCONNOR-MCCOURT, MAUREEN D.
申请号：
EP09813930
公开号：
EP2326670A4
申请日:
2009.09.17
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The invention provides hetero-multivalent ligand binging agents (traps) for members of the TGF-beta superfamily, as well as methods for making and using such constructs. In an embodiment of the invention there is provided a hetero-multivalent binding agent with affinity for a member of the TGF-beta superfamily. The agent comprises the general structure I: (<；bd1>；-linker1)k-[{<；bd1>；-linker2-<；bd2>；-linker3f-}n-(<；bd3>；)m-(linker4-<；bd4>；)d]h, where bd1, bd2, bd3 and bd4 are polypeptide binding domains having an affinity for different sites on the same member or for different members of the TGF-beta superfamily； at least two of bd1, bd2, bd3, and bd4 are different from each other.
