Children's Medical Center Corporation;Dana-Farber Cancer Institute, Inc.
发明人:
申请号：
EP18161487.6
公开号：
EP3406267A1
申请日:
2012.03.26
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present embodiments provide for compositions and methods that regulate microRNA-binding protein-mediated miRNA biogenesis； for example Lin28-mediated biogenesis of let-7； and in particular Lin28A-recruited 3' terminal uridylyl transferase (TUTase) uridylation of pre-let-7. A particular embodiment provides compositions and methods for screening for agents that inhibit TUTase-dependent Lin28A-mediated repression of let-7 miRNA.
