Richard I. Gregory,Elena Piskounova,Dimitrios Iliopoulos
申请号：
US14269041
公开号：
US09938354B2
申请日:
2014.05.02
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present embodiments provide for compositions and methods that regulate microRNA-binding protein-mediated miRNA biogenesis for example Lin28-mediated biogenesis of let-7 and in particular Lin28A-recruited 3′ terminal uridylyl transferase (TUTase) uridylation of pre-let-7. A particular embodiment provide compositions and methods for screening for agents that inhibit TUTase-dependent Lin28A-mediated repression of let-7 miRNA.
