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SUSPENSIONS HAUTEMENT CONCENTRÉES DE FAIBLE VISCOSITÉ
专利权人:
THE UNIVERSITY OF TEXAS SYSTEM;BOARD OF REGENTS
发明人:
JOHNSTON, KEITH, P.,MAZUSKI, MARIA, ANDREA,ENGSTROM, JOSHUA,RODRIGUES, MIGUEL, ANGELO
申请号:
EP09826617
公开号:
EP2376522A4
申请日:
2009.11.10
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The present invention also provides a high concentration low viscosity suspension of an pharmaceutically acceptable solvent with one or more sub-micron or micron-sized non-crystalline particles comprising one or more proteins or peptides. Optionally one or more additives in the pharmaceutically acceptable solvent to form a high concentration low viscosity suspension with a concentration of at least 20 mg/ml and a solution viscosity of between 2 and 100 centipoise that is suspendable upon shaking or agitation, wherein upon delivery the one or more sub-micron or micron-sized peptides dissolves and do not form peptide aggregates syringeable through a 21 to 27-gauge needle.
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