Described are low viscosity, hypotonic formulations containing one or more proteins, e.g., antibodies, at high concentration, uses of the formulations, and articles of manufacture. In particular, the formulations are useful and beneficial for the subcutaneous administration or delivery of a high concentration of a protein drug, such as an antibody, to a subject who is afflicted with a disease or condition that is treatable by the protein drug.La presente invención se refiere a una formulación, caracterizad porque comprende una proteína concentrada en una cantidad mayor que 100 mg/ml y menor que 200 mg/ml, un tonificante de una sal y un regulador de pH presentes en una cantidad combinada de 100 mM a 120mM y un agente tensoactivo, en donde la formulación tiene una osmolaridad de menos que 290 mOsm y tiene una viscosidad de menos que 40.
