A method for suppressing the isomerization of a monospecific sc(FV)2

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专利权人:

发明人:

IGAWA TOMOYUKI

申请号：

IN9530/DELNP/2007

公开号：

IN258224B

申请日:

2007.12.10

申请国别(地区):

IN

年份:

2013

代理人:

摘要：

The present inventor discovered stabilizing agents/stabilizing conditions for suppressing isomerization reactions of sc(Fv)2.  It was also discovered that the above-mentioned isomerization reactions can be suppressed through use of freeze-dried formulations.  As disclosed herein, by applying the discovered stabilizing agents/stabilizing conditions or the freeze-dried formulation, the isomerization reaction of an sc(Fv)2-type molecule from the bivalent scFv type to the single chain diabody type, and/or the isomerization reaction from a single chain diabody type to a bivalent scFv type can be suppressed in both directions or one direction.

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中国工程科技知识中心

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